Health Encyclopedia

Vernal conjunctivitis

Definition

Vernal conjunctivitis is long-term (chronic) swelling (inflammation) of the outer lining of the eyes. It is due to an allergic reaction.

Causes

Vernal conjunctivitis often occurs in people with a strong family history of allergies. These may include allergic rhinitis, asthma, and eczema. It is most common in young males, and most often occurs during the spring and summer.

Symptoms

Symptoms include:

Burning eyes.
Discomfort in bright light (photophobia).
Itching eyes.
The area around the cornea where the white of the eye and the cornea meet (limbus) may become rough and swollen.
The inside of the eyelids (most often the upper ones) may become rough and covered with bumps and a white mucus.
Watering eyes.

Exams and Tests

The health care provider will perform an eye exam.

Treatment

Avoid rubbing the eyes because this can irritate them more.

Cold compresses (a clean cloth soaked in cold water and then placed over the closed eyes) may be soothing.

Lubricating drops may also help soothe the eye.

If home-care measures do not help, you may need to be treated by your provider. Treatment may include:

Antihistamine or anti-inflammatory drops that are placed into the eye
Eye drops that prevent a type of white blood cell called mast cells from releasing histamine (may help prevent future attacks)
Mild steroids that are applied directly to the surface of the eye (for severe reactions)

The FDA has recently approved cyclosporine A 0.1%, a mild form of the anti-cancer drug for acute episodes of vernal conjunctivitis. It may also help prevent recurrences.

Outlook (Prognosis)

The condition continues over time (is chronic). It gets worse during certain seasons of the year, most often in the spring and summer. Treatment may provide relief.

Possible Complications

Complications may include:

Continuing discomfort
Reduced vision
Scarring of cornea

When to Contact a Medical Professional

Contact your provider if your symptoms continue or get worse.

Prevention

Using air conditioning or moving to a cooler climate may help prevent the problem from getting worse in the future.

References

Barney NP. Allergic and immunologic diseases of the eye. In: Burks AW, Holgate ST, O'Hehir RE, et al, eds. Middleton's Allergy: Principles and Practice. 9th ed. Philadelphia, PA: Elsevier; 2020:chap 38.

Cho CB, Boguniewicz M, Sicherer SH. Ocular allergies. In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Textbook of Pediatrics. 21st ed. Philadelphia, PA: Elsevier; 2020:chap 172.

Nehls SM. Vernal and atopic keratoconjunctivitis. In: Mannis MJ, Holland EJ, eds. Cornea. 5th ed. Philadelphia, PA: Elsevier; 2022:chap 43.

Rubenstein JB, Spektor T. Allergic conjunctivitis. In: Yanoff M, Duker JS, eds. Ophthalmology. 5th ed. Philadelphia, PA: Elsevier; 2019:chap 4.7.

US Food and Drug Administration. FDA approves first generic of Restasis. www.fda.gov/news-events/press-announcements/fda-approves-first-generic-restasis. Updated February 2, 2022. Accessed June 8, 2022.

Yucel OE, Ulus ND. Efficacy and safety of topical cyclosporine A 0.05% in vernal keratoconjunctivitis. Singapore Med J. 2016;57(9):507-510. PMID: 26768065 pubmed.ncbi.nlm.nih.gov/26768065/.

Review Date:2/17/2022
Reviewed By:Franklin W. Lusby, MD, Ophthalmologist, Lusby Vision Institute, La Jolla, CA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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